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More importantly, a growing body of research reveals that these hepatoprotective effects do not stem from direct liver-targeted actions of TCM components but are achieved through an indirect pharmacological model: TCM acts as a 'modulator' to reshape the GM structure, which subsequently alters the profile and levels of microbiota-derived intermediary substances (e.g., metabolites such as SCFAs, BAs, TMAO, LPS, etc.)

For example, metabolic syndrome is characterized by several metabolic abnormalities such as large abdominal circumference, high blood pressure, high blood glucose, high triglyceride levels, and low HDL cholesterol levels, and is associated with an increased risk of CVD, type 2 diabetes, and stroke

Each condition was performed in duplicate